In this clip it's 'revealed' that deciding that a live-action Family Guy would be a Bad Idea, it was also unwise to use the following people as the voices of the other characters: Kathy Griffin (Lois), Dane Cook (Chris), Queen Latifah (Meg)

Also worth noting that the clip ones with a shameless plug gag for the season 4 DVD which I didn't end up buying because I'm disappointed by FG DVD's compared to the more extensive audio commentaries and frills you get on Simpsons DVDs.